Product Name:Crospovidone
Chemical Description:Croslinked PVP,Crospovidone,Insoluble PVPPollyvinylpolypyrrolidone
INCI/CTFA:Insoluble PVP
Pharmacopeia Name:Crospovidone (Crospovidonum)
CAS NO.:9003-39-8,25249-54-1
Formula Structure:
Product Properties: Crospovidone is hygroscopic,insoluble in water and all other common solvents,but it swells rapidly in aqueous solutbition without any gel froms.Its; classified as Crospovidone Type A and Type B according to the different particle size.
Specifications:
|
Product |
Crospovidone Type A |
Crospovidone Type B |
|
Appearance |
White or yellowish-white powder or flakes |
|
|
Identifications |
Meet ID Tests |
|
|
Solubility |
Practically insoluble in water,in alcohol and in methylene chloride |
|
|
Water- soluble substances |
1.0% max |
1.0% max |
|
pH((1% in water) |
5.0 –8.0 |
5.0 –8.0 |
|
Loss on Drying |
5.0% max. |
5.0% max. |
|
Sulphated Ash |
0.1% max. |
0.1% max. |
|
Nitrogen content |
11.0 -12.8 % |
11.0 -12.8 % |
|
Impurity A |
10 ppm max. |
10 ppm max. |
|
Peroxide(As H2O2) |
400 ppm max. |
1000 ppm max. |
|
Heavy Metal |
10 ppm max. |
10 ppm max. |
|
Particle Size(μm), ≥80% |
50-300 |
5-50 |
Applications:
In the pharmaceutical industry,Crospovidone are widely used as
1)Disintergrating agent,
2)Stabilizer for suspension,
3)Moisture Absorbent,
4)Complextant of Polyphenols and Tannin for the extract formulations.
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